NHD Global
Growth Hormone & IGF · Ghrelin-receptor agonist research
Scientific Product Dossier
MK-677, also called ibutamoren, is a non-peptide research compound that activates the ghrelin receptor and raises growth hormone and IGF-1. In older-adult trials, fat-free mass increased, but strength and physical function did not improve. Fat-free mass includes water and tissues other than fat; it is not a direct measure of muscle gain. Some blood-sugar measures worsened. A separate hip-fracture trial stopped early after a heart-failure signal. These findings describe specific clinical trials, not established benefits from NHD research material.
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.
Product identity
Literature reference parameters
Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.
A target-to-pathway view grounded in the linked research records.
Reported research findings
Reported outcomes are paired with their experimental model and evidence boundary.
Fat-free mass changed by +1.1 kg versus −0.5 kg with placebo, but strength and physical function did not improve.
65 healthy adults aged 60–81; fasting glucose increased and insulin sensitivity decreased.
Read the primary studyA 123-patient phase IIb study was terminated early after a congestive-heart-failure signal.
The result prevents a benefit-only summary of the development history.
Read the primary studyCatalog options
Pack-level catalog data; lot-level controls remain document-specific.
Small-molecule research compound · 5 mg/vial nominal · 10-vial pack · chemical form, identity and assay controlled by lot specification.
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.
Analytical interpretation
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Published studies and regulatory records, not customer testimonials or usage guidance.
Nass R, et al. Annals of Internal Medicine. 2008. PMID 18981485.
View primary recordAdunsky A, et al. Archives of Gerontology and Geriatrics. 2011. PMID 21067829.
View primary recordThird-party publications selected for direct relevance.
Nass R, et al. Annals of Internal Medicine. 2008. PMID 18981485.
Adunsky A, et al. Archives of Gerontology and Geriatrics. 2011. PMID 21067829.
Concise answers for researchers comparing identity, evidence and catalog variants.
In a two-year trial of healthy older adults, daily ibutamoren raised growth hormone and IGF-1 and increased fat-free mass, while placebo lost some. Strength and physical function did not improve, and fasting glucose rose with reduced insulin sensitivity. A separate hip-fracture study found IGF-1 increased but most functional measures did not improve, and it was stopped early after a congestive-heart-failure signal. So the honest summary is: measurable hormonal and body-composition changes, without demonstrated functional benefit and with safety concerns.
The human findings here come from specific clinical trials of ibutamoren in defined patient groups. Research materials labeled MK-677 are research materials for laboratory work, not the same tested medicine. Their composition, purity and handling are separate from published trial data. A laboratory result with catalog material does not show a health effect, and clinical outcomes cannot be assumed to apply to a research chemical or any blend. Known safety limits from the trials remain tied to the molecule.
No. Fat-free mass increased, but strength and physical-function measures did not improve.
No. Human trials exist, but ibutamoren is not an FDA-approved active ingredient.
Family-level identifiers organize the catalog. Confirm the supplied form, identity and release criteria using the applicable product specification and ask which lot records are available.
A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.
Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.
Knowledge center
Owned educational content connected to this family.
A two-year trial in 65 healthy older adults is often quoted for lean-mass change. The same paper also reported no improvement in strength or…
Updated October 1, 2026
MK-677, MK-0677 and ibutamoren are names found across the same development history. The existence of human trials does not mean the compound is an…
Updated October 1, 2026Knowledge tools
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.
Technical procurement
Selected: MK75 · 5 mg × 10 vials
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