NHD Global
Growth Hormone & IGF · Ghrelin-receptor agonist research
Scientific Product Dossier
Ibutamoren (MK-677/MK-0677) is an oral ghrelin-receptor agonist and growth-hormone secretagogue studied in older adults. A two-year trial increased fat-free mass but did not improve strength or physical function and worsened glucose-related measures. A separate hip-fracture study ended early after a congestive-heart-failure safety signal. Ibutamoren is not FDA approved.
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.
Product identity
Literature reference parameters
Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.
A target-to-pathway view grounded in the linked research records.
Reported research findings
Reported outcomes are paired with their experimental model and evidence boundary.
Fat-free mass changed by +1.1 kg versus −0.5 kg with placebo, but strength and physical function did not improve.
65 healthy adults aged 60–81; fasting glucose increased and insulin sensitivity decreased.
Read the primary studyA 123-patient phase IIb study was terminated early after a congestive-heart-failure signal.
The result prevents a benefit-only summary of the development history.
Read the primary studyCatalog options
Pack-level catalog data; lot-level controls remain document-specific.
Small-molecule research compound · 5 mg/vial nominal · 10-vial pack · chemical form, identity and assay controlled by lot specification.
Request by lot: CoA, identity and assay summary
Document availability is stated honestly and can vary by catalog variant or lot.
Analytical interpretation
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Published studies and regulatory records, not customer testimonials or usage guidance.
Nass R, et al. Annals of Internal Medicine. 2008. PMID 18981485.
View primary recordAdunsky A, et al. Archives of Gerontology and Geriatrics. 2011. PMID 21067829.
View primary recordThird-party publications selected for direct relevance.
Nass R, et al. Annals of Internal Medicine. 2008. PMID 18981485.
Adunsky A, et al. Archives of Gerontology and Geriatrics. 2011. PMID 21067829.
Concise answers for researchers comparing identity, evidence and catalog variants.
No. Fat-free mass increased, but strength and physical-function measures did not improve.
No. Human trials exist, but ibutamoren is not an FDA-approved active ingredient.
Family-level identifiers organize the catalog, while the applicable product specification and lot-specific COA control the supplied form, identity and release results.
A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.
Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.
Knowledge center
Owned educational content connected to this family.
A two-year trial in 65 healthy older adults is often quoted for lean-mass change. The same paper also reported no improvement in strength or…
Updated August 28, 2026
MK-677, MK-0677 and ibutamoren are names found across the same development history. The existence of human trials does not mean the compound is an…
Updated August 28, 2026Knowledge tools
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.
Technical procurement
Selected: MK75 · 5 mg × 10 vials
Tell us what you need. Your enquiry will be routed to the appropriate contact for catalog numbers, availability and quotation details.
